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$AMPE Positive Results Pivotal Phase 3 Trial of Ampion in Severe Osteoarthritis-of-the Knee

- Primary endpoint of OMERACT-OARSI responder rate at 12 weeks achieved statistical significance (p < 0.001) – Ampion™ is the first therapy indicated for signs and symptoms for severe osteoarthritis of the knee and will address a significant treatment gap – Conference call, December 14, at 6:30 a.m. MT (8:30 ET)

ENGLEWOOD, Colo., Dec. 14, 2017 – Ampio Pharmaceuticals, Inc. (NYSE MKT: AMPE) today reported that the Phase 3 clinical trial of Ampion™ met its primary endpoint with 71% of Ampion™ treated patients meeting the OMERACT-OARSI responder criteria, which exceeds the physician reported threshold of 30% for a meaningful treatment in severe osteoarthritis of the knee (p < 0.001). Responders experienced, on average a 53% decrease in pain as measured by WOMAC A and a 50% improvement in function as measured by WOMAC C and a 45% improvement in quality of life as measured by Patient Global Assessment (PGA). In the secondary endpoints, Ampion™ treated patients achieved statistical significance in a composite endpoint of pain and function from baseline in both categories at 12 weeks (p < 0.001), which was supported by an increase in quality of life as measured by patient global assessment (PGA) (p < 0.001). When treated with Ampion™ (n=144), patients experienced significant improvement in a composite endpoint of pain and function compared to all KL 4 saline-treated patients (n=206) in Ampion™ phase 3 clinical trials (p < 0.001).

If approved, Ampion™ would be the first intra-articular injection to treat the signs and symptoms of patients with severe osteoarthritis of the knee (Kellgren-Lawrence x-ray grade 4).  In order to support a label for signs and symptoms, Ampion™ was asked to demonstrate clinical efficacy in a composite response of pain, function and be supported by quality of life.

Ampion™ was well tolerated with treatment-emergent adverse events (TEAEs) comparable to those of placebo in all single-injection studies of Ampion™. There were no drug-related serious TEAEs associated with the Ampion™ arm. The safety and tolerability profile of Ampion™ is consistent with previous studies.  To date, Ampion™ has been given to over 900 patients with no reported drug-related serious TEAEs.

Ampio plans to present a more detailed analysis of the Phase 3 and pooled data at an upcoming scientific meeting as well as submission for publication.

“We are very pleased with the positive Phase 3 data as we believe that Ampion™ will address an unmet medical need, providing severely diseased patients a non-opioid option that not only reduces pain, but also improves function and quality of life in a meaningful way” said Michael Macaluso, Chairman and CEO, Ampio Pharmaceuticals. “We are hopeful that Ampion™ will serve as a safe and effective treatment for an incurable, progressive disease that afflicts 21 million people in the U.S. and over 200 million people worldwide who suffer from osteoarthritis. We look forward to working closely with the U.S. Food and Drug Administration (FDA) as we prepare to submit our Biologics License Application (BLA) for Ampion™.”

In this multi-center, randomized study of 144 KL4 patients with severe OAK of the knee, patients received either a single 4mL intra-articular injection of Ampion™ or placebo at a ratio of 6:1. The primary endpoint of responder analysis using OMERACT-OARSI was evaluated at 12-weeks following a single injection.

The OMERACT-OARSI response composite looks to assess three core symptoms of OAK (pain, function, and patient’s global assessment) as a single variable. For each domain, a response requires both a relative and an absolute change. OMERACT-OARSI response is defined as having a high improvement in pain or function and/or a clinically meaningful improvement in two of three core measurements of OA: pain, function or quality of life. Specifically, to be considered a responder, a patient must demonstrate improvement in WOMAC A (pain) or WOMAC C (function) of ≥50% and absolute change of ≥1.0 point on a 5 point Likert (0-4) scale, or ≥20% improvement in at least 2 of the following 3 categories: WOMAC A, WOMAC C,  or Patient Global Assessment, with a 0.5 point change on a 5 point (0-4) pain scale.

Conference Call
At 8:30 a.m. ET tomorrow, Ampio’s management will host a conference call to discuss the Phase 3 clinical results.  The dial-in number for the conference call is (877) 260-1479 for U.S./Canada participants and (334) 323-0522 for local participants, with Participant Passcode # 6638480. A live webcast of the conference call can also be accessed through the “Investors” tab on the Ampio Pharmaceuticals website at www.ampiopharma.com. A webcast replay will be available online after the call.

About Osteoarthritis
Osteoarthritis (OA) is an incurable and progressive disorder of the joints involving degradation of the intra-articular cartilage, joint lining, ligaments, and bone. The incidence of developing osteoarthritis of the knee over a lifetime is approximately 45%. As this disease is associated with age, obesity, and diabetes, this number will continue to grow. Certain risk factors in conjunction with natural wear and tear lead to the breakdown of cartilage. Osteoarthritis is caused by inflammation of the soft tissue and bony structures of the joint, which worsens over time and leads to progressive thinning of articular cartilage. Other symptoms include narrowing of the joint space, synovial membrane thickening, osteophyte formation and increased density of subchondral bone.

About Ampio Pharmaceuticals
Ampio Pharmaceuticals, Inc. is a development stage biopharmaceutical company primarily focused on the development of therapies to treat prevalent inflammatory conditions for which there are limited treatment options. We are developing compounds that decrease inflammation by (i) inhibiting specific pro-inflammatory compounds by affecting specific pathways at the protein expression and the transcription level; (ii) activating specific phosphatase or depletion of the available phosphate needed for the inflammation process; and (iii) decreasing vascular permeability.

Forward-Looking Statements
Ampio’s statements in this press release that are not historical fact, and that relate to future plans or events, are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements can be identified by the use of words such as “believe,” “expect,” “plan,” “anticipate,” and similar expressions. These forward-looking statements include statements regarding Ampio’s clinical trials of our Ampion™ product. The risks and uncertainties involved include those detailed from time to time in Ampio’s filings with the Securities and Exchange Commission, including without limitation, under Ampio’s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. Ampio undertakes no obligation to revise or update these forward-looking statements, whether as a result of new information, future events or otherwise.

Company Contact
Tom Chilcott
Chief Financial Officer
Phone: (720) 437-6500
tchilcott@ampiopharma.com

Media Contact
Chiara Russo
Director, Investor Relations
Lavoie Health Science
Phone: (617) 374-8800 ext. 112
crusso@lavoiehealthscience.com

Thursday, December 14th, 2017 Uncategorized Comments Off

$SIEB $OSTK Execute Letter of Intent to Offer Discount Trading

SALT LAKE CITY and NEW YORK, Dec. 14, 2017  — Overstock.com (NASDAQ:OSTK), its subsidiary tZERO and Siebert Financial Corp. (NASDAQ:SIEB) have signed a letter of intent to enter into a partnership to offer deeply discounted online trading in Q1, 2018, when the transaction is slated to close. Under terms of the agreement, any investor in America who accesses the Muriel Siebert & Co. Inc. portal at Overstock would be able to conduct online trading of US equities for $2.99 per trade through the platform. In addition, Overstock plans to introduce a new tier to its Club O loyalty and membership rewards program to offer that elite membership level the opportunity for online trading at an even deeper discount of $1.99 per trade.

Overstock and Siebert Financial Corp. intend to deliver institutional quality financial services to clients, enhancing the mutual benefits of this paradigm-changing partnership. New customers subscribing to the discount brokerage suite of products would be offered best-in-class services including Smart Order and Routing and Execution services by tZERO’s broker-dealer Speedroute, a FINRA firm, and Clearing Services through StockCross Financial Services, a FINRA firm and affiliate of Siebert Financial Corp.

For years, millions of consumers have trusted Overstock with home, and more recently, auto purchases. Overstock currently delivers world-class service and award-winning customer experiences to over 30 million shoppers per month, as evidenced by its 2017 Loyalty360 Customer Award in Operational Excellence and its six consecutive Mobile Web Awards for its shopping apps.

Siebert Financial Corp. was founded in 1967 by Muriel Siebert, the first woman to own a seat on the New York Stock Exchange and the first to head one of its member firms, Muriel Siebert & Co., Inc. Ms. Siebert was also a pioneer by transforming her firm into a discount brokerage in 1975 on the first day NYSE members were allowed to negotiate commissions.

Of the newly announced intended deal, Overstock CEO Patrick M. Byrne said, “There are multiple complementary facets of the two companies’ trading ecosystems and today they align perfectly to deliver unmatched value to investors. Mickie Siebert showed that women can make it big on Wall Street, and women have always been an important part of Overstock’s success too, so there is a correlation in our pioneering traditions. Just last week, Overstock and its subsidiary, Medici Ventures, signed the Parity Pledge vowing to empower women into leadership positions. With a significant majority of Overstock’s loyal base being women, it is our distinct honor to partner with a legendary woman-owned firm led by Gloria E. Gebbia. Mrs. Gebbia exemplifies all that is great about the advancement of women in leadership and we are honored to deliver the lowest pricing to our growing user base with such a trusted and iconic partner.”

Gloria E. Gebbia, majority shareholder and board member of Siebert Financial said, “We are pleased to partner with Overstock and its founder Dr. Patrick Byrne, who has been a visionary leader in e-commerce. We continue to uphold the enduring vision and legacy of founder Mickie Siebert with our focus on integrity and the safety of investments, as there is no substitute for understanding the cares and concerns of our clients. Together our efforts will be directed towards delivering quality products and services designed to serve the financial needs of our clients, which will always be our top priority.”

While maintaining the industry’s deepest discounts for online trading, this partnership plans to introduce the rollout of new products and services such as Blockchain Trading, Crypto Products, and Robo Advisory, along with Free IRA products.

Media Contacts:
For Overstock, tZERO and Medici Ventures:
Alexandra Sotiropoulos
+1 212-754-5615
asotiropoulos@intermarket.com

For Siebert Financial Corp.:
LHK Communications, LLC
Laura Hynes-Keller, +1-212-758-8602
laurahk@lhkcommunications.com

About Overstock.com

Overstock.com, Inc. Common Shares (NASDAQ:OSTK) / Series A Preferred (Medici Ventures’ t0 platform: OSTKP) / Series B Preferred (OTCQX:OSTBP) is an online retailer based in Salt Lake City, Utah that sells a broad range of products at low prices, including furniture, décor, rugs, bedding, and home improvement. In addition to home goods, Overstock.com offers a variety of products including jewelry, electronics, apparel, and more, as well as a marketplace providing customers access to hundreds of thousands of products from third-party sellers. Additional stores include Worldstock.com, dedicated to selling artisan-crafted products from around the world. Forbes ranked Overstock in its list of the Top 100 Most Trustworthy Companies in 2014. Overstock regularly posts information about the company and other related matters under Investor Relations on its website, http://www.overstock.com.

About Siebert Financial Corp.

Siebert Financial is a holding company that conducts its retail discount brokerage business through its wholly-owned subsidiary, Muriel Siebert & Co., Inc. The firm became a member of the NYSE in 1967, when Ms. Siebert became the first woman to own a seat on the Exchange. In addition, in 2014 the Company began business as a registered investment advisor through a wholly-owned subsidiary, Siebert Investment Advisors, Inc. Siebert Financial, based on Wall Street in New York City, serves clients through its branch offices located nationwide and globally online. www.siebertnet.com

Cautionary note regarding forward-looking statements

Statements in this press release that are not statements of historical or current fact constitute “forward looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward looking statements involve risks and uncertainties and known and unknown factors that could cause the actual results of the Siebert Financial Corp. (the “Company”) to be materially different from historical results or from any future results expressed or implied by such forward looking statements, including without limitation: changes in general economic and market conditions; changes and prospects for changes in interest rates; fluctuations in volume and prices of securities; changes in demand for brokerage services; competition within and without the brokerage business, including the offer of broader services; competition from electronic discount brokerage firms offering greater discounts on commissions than the Company; the prevalence of a flat fee environment; limited trading opportunities; the method of placing trades by the Company’s customers; computer and telephone system failures; the level of spending by the Company on advertising and promotion; trading errors and the possibility of losses from customer non-payment of amounts due; other increases in expenses and changes in net capital or other regulatory requirements.  As a result of these and other factors, the Company may experience material fluctuations in its operating results on a quarterly or annual basis, which could materially and adversely affect its business, financial condition, operating results, and stock price, as well as other risks detailed in the Company’s filings with the Securities and Exchange Commission (“SEC”).  Accordingly, investors are cautioned not to place undue reliance on any such “forward-looking statements.” The Company undertakes no obligation to update the information contained herein or to publicly announce the result of any revisions to such “forward-looking statements” to reflect future events or developments. An investment in the Company involves various risks, including those mentioned above and those, which are detailed from time to time in the Company’s SEC filings, copies of which may be obtained from the Company or through the SEC’s website.

Notice to Investors

This communication is provided for informational purposes only and is neither an offer to sell nor a solicitation of an offer to buy any securities in the United States or elsewhere.

About Stockcross Financial Services, Inc.

StockCross Financial Services, Inc. is one of the largest privately-owned brokerage firms in the nation. Established in 1971, it has spent many years providing financial guidance and excellent customer service to its clients. Branch offices are located throughout the nation and are staffed with knowledgeable and experienced representatives. Online investment services and phone support offer clients around the world instant and current information on their accounts. StockCross consistently delivers on its full scope of offerings including fixed-income products, online or broker-assisted equity trading, ESOS/ESOP programs across the globe through advanced online trading capabilities, and is a self-clearing firm specializing in fixed income securities, outstanding customer service, and client investment choices. StockCross is headquartered in Beverly Hills. Member FINRA | SIPC | EST. 1971

Specialties

Online Trading, Corporate Services, Fixed Income, Equities, Institutional Trading, Capital Commitment and Market Making, Retail Investment Services.

About Medici Ventures

Launched in 2014, Medici Ventures is a wholly owned subsidiary of Overstock.com, Inc., created to leverage blockchain technology to solve real-world problems with transparent, efficient and secure solutions. Medici Ventures has a growing portfolio of groundbreaking blockchain-focused investments, including t0.com, Peernova, Bitt, SettleMint, Factom, and IdentityMind, Spera and Symbiont. The company’s majority-owned financial technology company, t0.com, executed the world’s first blockchain-based stock offering in December 2016.

About tZERO         

t0.com, Inc. (“tZERO“)  is a majority owned subsidiary of Overstock.com, focusing on the development and commercialization of financial technology (FinTech) based on cryptographically-secured, decentralized ledgers – more commonly known as blockchain technologies. Since its inception, tZERO has pioneered the effort to bring greater efficiency and transparency to capital markets through the integration of blockchain technology. More information is available at tZERO.com.

Thursday, December 14th, 2017 Uncategorized Comments Off

$OHGI Executes Term Sheet to Acquire 123Wish

LONDON, Dec. 14, 2017 — One Horizon Group, Inc. (NASDAQ:OHGI) today announced that it has entered into a term sheet that includes the main provisions of the definitive agreements to acquire a majority interest in ONCE IN A LIFETIME LLC, d/b/a 123Wish.

123Wish in the Apple App Store and available next month on Google Play and www.123wish.com is a subscription-based, social-media platform that provides users with unique opportunities to enjoy personalized, dream experiences with some of the world’s most renowned influencers, celebrities, professional athletes, fashion designers, and artists while supporting a diverse range of charities.

By way of example, a 123Wish experience includes the chance to star in a Jake Paul YouTube video. Jake Paul’s music video “It’s Everyday Bro featuring Team 10” (Jake’s team of relevant social media influencers) has over 160 million views and frequently released Jake Paul videos reach viewership in the tens of millions.

123Wish was co-founded in early 2016 by real estate mogul and serial technology entrepreneur Andrew Resnick who has developed and launched web properties that reach tens of millions of unique visitors a month and Natalia Diaz whose digital agency MOA Digital Works specializes in mobile and web commerce and gaming development for several Fortune 500 and other innovative company clients that rely on social-media monetization.

Recognizing that fundamental to the 123Wish business model was building relationships with the most influential members of Generation Z, Natalia engaged Gen Z entrepreneur and venture capitalist Patrick Finnegan to harness those relationships and manifest the vision of being an authentic lifestyle brand that Gen Z wanted to embrace.

Patrick brought his partners Jake Paul (more than 12 million YouTube subscribers and more than 10 million Instagram followers) and Cameron Dallas (more than 5 million YouTube subscribers and more than 20 million Instagram followers) and their venture capital fund, TGZ Capital, took a significant equity interest in 123Wish. Their involvement brought immediate momentum to the 123Wish business, which has access to more than 80 million internal and more than 300 million external subscribers and followers.

“Subscribers, fans and likes have become a new form of currency and given the rapid expansion of cryptocurrency, we see a world where social media platform-based commerce and even charitable contribution will be driven by digital coins that allow for efficient and transparent transactions,” said 123Wish Co-Founder Andrew Resnick. “Using coins as a vehicle for transfers of funds affords unique opportunities to educate the next generations about contributing to the greater good and social media is the perfect outlet to expand and support these systems.”

“While the agreement is subject to customary conditions including completion of due diligence and approvals, we expect to close in the first quarter of 2018 and we are confident the acquisition will be accretive in 2018,” said One Horizon Group’s Founder and CEO, Mark White. “We are excited to be working with the 123Wish team and we are certain that this transaction will deliver significant value to OHGI shareholders.”

Each curated 123Wish experience supports a philanthropic cause of the celebrity or influencer’s choosing or is randomly matched to a non-profit. Once the charitable contribution goal for an experience has been met and the timeframe for entry has expired, 123Wish randomly selects the winner. Subscribers have exclusive opportunities to interact with experience contributors and everyone who enters receives a specialized gift for participating. Corporate sponsors of the experiences include some of the world’s most widely recognized brands that seek to connect with 123Wish subscribers and are aligned with the celebrity or influencer’s desire to make a positive social impact.

“Social media influencers and celebrities are building brands with unprecedented reach given their ability to connect with their subscribers and fans on an emotional level,” said 123Wish Co-Founder and CEO Natalia Diaz. “As I described in speaking with Forbes earlier this year, working with influencers gives advertisers the ability to more specifically address their target demographic as compared with traditional forms of advertising. In order to expand the reach of 123Wish and to give investors an opportunity to participate in the next wave of social media that speaks to Gen-Zers and Millennials who place a higher value on human experiences that contribute to the greater good than high-cost material items, we welcome the desire of One Horizon Group to allow us to further build our business as part of a NASDAQ-listed technology company.”

“In founding 123Wish, Natalia and I recognized that through our close friends and business contacts, we have access to some of the world’s most popular social media influencers, celebrities, professional athletes, fashion designers, and artists,” added 123Wish Co-Founder Andrew Resnick. “We also realized that what attracted us to these people was a fundamental desire to contribute our talents to make the world a better place for everyone. 123Wish not only provides subscribers with the possibility of participating in one-of-a-kind experiences; the company has created an engaging community of talent and fans collaborating to take significant and lasting action on social issues. After spending time with One Horizon Group’s Founder and CEO Mark White, we realized that our companies are philosophically aligned and that by combining our strengths, we will be able to build a stronger organizational foundation, expand our reach even further, and importantly, make a greater social impact for good.”

About One Horizon Group, Inc.

One Horizon Group, Inc. (NASDAQ:OHGI) is a reseller of secure messaging software for the growing gaming, security and education markets including in China and Hong Kong.  For more information on the Company please visit http://www.onehorizongroup.com/investors-overview/.

Darrow Associates Contacts for OHGI

Bernie Kilkelly
(516) 236-7007
bkilkelly@darrowir.com

Jordan Darrow
(512) 551-9296 
jdarrow@darrowir.com
Thursday, December 14th, 2017 Uncategorized Comments Off

$VSQTF Taps Guy Halford-Thompson to Accelerate Growth of Its Blockchain Portfolio

VANCOUVER, British Columbia, Dec. 14, 2017 — Victory Square Technologies Inc. (“Victory Square” or the “Company“) (CSE:VST) (OTC:VSQTF) (FWB:6F6) is pleased to announce the appointment of Guy Halford-Thompson, co-founder of BTL Group (TSX-V:BTL) (OTC:BTLLF) to its Advisory Board. Mr. Halford-Thompson is a globally recognized pioneer and visionary in blockchain technology and will play a key role in growing and scaling Victory Square’s current portfolio of blockchain companies.

Victory Square has been a long-time supporter of Halford-Thompson’s vision for incorporating blockchain technology into enterprise business, having invested in and incubated his company, the BTL Group three years ago. BTL Group was the first publicly traded blockchain company in Canada and has grown to a market cap of $250M on the TSX Venture Exchange. The product BTL is best known for, Interbit, a blockchain development platform that leverages cutting edge tools to empower developers to build enterprise-grade blockchain-based applications. BTL has partnered with large institutions like Visa and BP to further explore the potential for private blockchains to reduce cost and increase efficiency.

“Guy has been a thought-leader in the blockchain space for years and has had tremendous success building one of Canada’s premier blockchain companies, the BTL Group,” said Shafin Diamond Tejani, Chief Executive Officer of Victory Square. “We are extremely excited and fortunate to have him join Victory Square due to his extraordinary vision and foresight on how blockchain will disrupt verticals that our portfolio companies operate in, such as Gaming, Health, Fintech, VR/AR/MR, and AI.”

Mr. Halford-Thompson will immediately begin advising VST portfolio companies Blockchain Assembly and FansUnite grow and scale their businesses, and will play a strategic role in Victory Square’s new partnership with the Blockchain Investment Consortium to identify the most promising and disruptive blockchain companies around the world.

“Victory Square played a key part helping BTL scale in its early days, and I’m extremely excited to join the team as an advisor,” said Mr. Halford-Thompson. “The leadership group at Victory Square has consistently shown an ability to identify large market opportunities, as well as the right teams to capitalize on them. They give them the funding, resources and relationships required to accelerate their growth and allow them to scale internationally.”

For further information about the Company, please contact:
Howard Blank, Director
Email: ir@victorysquare.com
Telephone: 604-928-6066

ABOUT VICTORY SQUARE TECHNOLOGIES INC.
Victory Square is a venture builder that creates, funds and empowers entrepreneurs predominantly focused on Blockchain Technology, Virtual Reality, Artificial Intelligence, Personalized Health, Gaming and Film. As a technology incubator, Victory Square invests in game-changing entrepreneurs who are provided access to education programs, global mentorship networks, distribution partners, creative workspaces, resources and other forms of operational support to help them scale internationally. For more information, please visit www.victorysquare.com.

FORWARD-LOOKING INFORMATION
This news release may include forward-looking information within the meaning of Canadian securities legislation, concerning the business of Victory Square. Forward-looking information is based on certain key expectations and assumptions made by the management of Victory Square, including future plans. Although Victory Square believes that the expectations and assumptions on which such forward-looking information is based are reasonable, undue reliance should not be placed on the forward-looking information because Victory Square can give no assurance that they will prove to be correct. Forward- looking statements contained in this news release are made as of the date of this news release. Victory Square disclaims any intent or obligation to update publicly any forward-looking information, whether because of new information, future events or results or otherwise, other than as required by applicable securities laws.

Thursday, December 14th, 2017 Uncategorized Comments Off

$LTEA Announces Partnership with European Cold-Pressed Juice Company Natur

- Long Island Iced Tea to Distribute Natur Brands in the Americas and Natur to Distribute Long Island Iced Tea Brands in Europe -

- Provides Long Island Iced Tea and Natur with Global Reach for their Complementary Products to Construct Diversified ‘Better-For-You’ Consumer Portfolio -

Farmingdale (Long Island), NY, Dec. 13, 2017 — Long Island Iced Tea Corp. (NasdaqCM: LTEA) (the “Company”), a growth-oriented company focused on the ready-to-drink (“RTD”) tea segment in the beverage industry, today announced the signing of two distribution agreements with Natur, a European hi-tech healthy food and beverage company. The Company will be the exclusive distributor of Natur’s branded products in North and South America, and Natur will be the exclusive distributor of the Company’s branded products in Europe.

The first of Natur’s products that the Company will begin to distribute is its Super Not-From-Concentrate (“SNFC”) line of juices, available in 250ml and 750ml bottle sizes. The SNFC juices are differentiated in their shelf life (31 days ambient and 180 days chilled) as well as their nutritional density from extracting high levels of nutrients from fruits or vegetables, all while maintaining a premium quality and taste. More information about Natur and its innovative product offerings is available at https://int.natur.eu.

Philip Thomas, Chief Executive Officer of the Company, commented, “We are very excited with the opportunity to distribute Natur’s hi-tech, better-for-you brands in North and South America. Its brands are supported by ‘farm-to-shelf’ traceability, and the company has access to outstanding research and development via its shareholder AMC.”

Robert Jan van Olm, Chief Executive Officer of Natur, added, “Long Island Iced Tea is a great partner for us in the US, having established an extensive distribution footprint across the Northeast of the US as well as emerging positions in Canada and Latin America. We believe their existing distribution position, underpinned by our effective e-commerce platforms which we will roll out and support in the US, will combine to create exciting growth opportunities. Reciprocal to this, we expect Natur to deliver similar benefits for the Long Island Tea brands in Europe.”

About Long Island Iced Tea Corp.

Headquartered in Long Island, NY, Long Island Iced Tea Corp. operates in the non-alcohol, ready-to-drink segment of the beverage industry. The Company’s flagship brand ‘The Original Long Island Brand Iced Tea®’, together with ‘The Original Long Island Brand LemonadeTM’ are marketed as premium beverages made with non-GMO ingredients. The company also imports and markets ‘ALO Juice®’ a functional Aloe Vera based beverage. The Company’s portfolio of premium brands sits within the ‘better-for-you’ category of the beverage industry, and are offered to consumers at an affordable price, reflecting the Company’s mission.  Its beverages are sold primarily through a network of regional chains and distributors, primarily on the East Coast and the Midwest of the United States, as well as Canada and Latin America. The Company’s website is www.longislandicedtea.com.

About Natur 

Natur is Europe’s first hi-tech health food & beverage company with a mission to revolutionize natural juice and snack consumption, allowing consumers to afford a better quality of life through natural and functional nutrition.  Natur offers 100% natural / organic juices and snacks with no additives, preservatives, and all are non-GMO.  Their focus is on the premium branded segment in which consumers are increasingly moving towards healthier alternatives, embracing the ‘snackification’ trend. Natur has a multi-channel route to market via leading retailers, foodservice partners, online subscription models and through to its own European flagship retail stores.

The company utilises novel production technologies, such as cold-pressed / HPP, and, Super-NFC (‘not-from-concentrate’) enabling them to offer uniquely competitive products with extended shelf life, while retaining their organoleptic properties. Natur’s cold pressed, raw juice portfolio benefits from a 31 days shelf life, while the Company’s Super-NFC nutrient dense and functional juice products have a shelf life of up to 6 months. Further, the Super-NFC brands allow for ambient transportation up to four weeks opening the doors to global export markets. The Company has forged a strategic partnership with one of its key shareholders, the AMC Group, a global leader of private label juice (with annual revenues exceeding $1.2B), which owns and controls its entire production and supply chain, allowing Natur to offer a truly holistic ‘farm to fridge’ experience.

Forward Looking Statements 

This press release includes statements of the Company’s expectations, intentions, plans and beliefs that constitute “forward looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934 and are intended to come within the safe harbor protection provided by those sections. These statements, which involve risks and uncertainties, relate to the discussion of the Company’s business strategies and its expectations concerning future operations, margins, sales, new products and brands, potential joint ventures, potential acquisitions, expenses, profitability, liquidity and capital resources and to analyses and other information that are based on forecasts of future results and estimates of amounts not yet determinable. These statements include any statement that does not directly relate to a historical or current fact. You can also identify these and other forward-looking statements by the use of such words as “may,” “will,” “should,” “expects,” “intends,” “plans,” “anticipates,” “believes,” “thinks,” “estimates,” “seeks,” “predicts,” “could,” “projects,” “potential” and other similar terms and phrases, including references to assumptions. These forward looking statements are made based on expectations and beliefs concerning future events affecting the Company and are subject to uncertainties, risks and factors relating to its operations and business environments, all of which are difficult to predict and many of which are beyond its control, that could cause its actual results to differ materially from those matters expressed or implied by these forward looking statements. These risks include possible accounting adjustments made in the process of finalizing reported financial results, the Company’s history of losses and expectation of further losses, its ability to expand its operations in both new and existing markets, its ability to develop or acquire new brands, its relationships with distributors, the success of its marketing activities, the effect of competition in its industry and economic and political conditions generally, including the current economic environment and markets. More information about these and other factors are described in the reports the Company files with the Securities and Exchange Commission, including but not limited to the discussions contained under the caption “Risk Factors.” When considering these forward looking statements, you should keep in mind the cautionary statements in this press release and the reports the Company files with the Securities and Exchange Commission. New risks and uncertainties arise from time to time, and the Company cannot predict those events or how they may affect it. The Company assumes no obligation to update any forward looking statements after the date of this press release as a result of new information, future events or developments, except as required by the federal securities laws.

Contacts:

For Long Island Iced Tea Corp.                                                                                      

Phil Thomas

1-855-542-2832

info@longislandteas.com

For Natur

Robert Jan van Olm 
pr@natur.eu
Wednesday, December 13th, 2017 Uncategorized Comments Off

$WPRT 2018 Emissions Certifications for L9N and B6.7N Natural Gas Engines

VANCOUVER, British Columbia, Dec. 13, 2017  — Cummins Westport Inc. (“CWI”) announced today that it has received certifications from both the U.S. Environmental Protection Agency (“EPA”) and Air Resources Board (“ARB”) in California for its 2018 L9N and B6.7N natural gas engines. Both engines meet California ARB optional Low NOx standards, as well as 2017 EPA greenhouse gas emission (“GHG”) requirements, making them some of the cleanest engines available today for truck and bus customers.

The L9N is certified to Californial ARB optional Low NOx standard of 0.02 g/bhp-hr ‒ a 90% reduction from engines operating at the current EPA NOx limit of 0.2 g/bhp-hr. The L9N offers ratings from 250 – 320 hp and 1,000 lb-ft peak torque, making it ideal for transit, shuttle and school bus, as well as medium-duty truck and refuse applications.

The B6.7N is certified to California ARB optional Low NOx standard of 0.1 g/bhp-hr – a 50% reduction from current EPA levels. Available with ratings from 200 – 240 hp and 560 lb-ft peak torque, the B6.7N is a great fit for school bus, shuttle, and medium-duty truck applications.

Based on the ISL G and ISB6.7 G natural gas engines, the 2018 L9N and B6.7N build on the experience gained from over 80,000 Cummins Westport engines currently in service and provide a present-day solution to urban air quality issues. In addition to ultra low emissions, the L9N and B6.7N feature a new engine control module with improved durability, on-board diagnostic (“OBD”) capability, an enhanced maintenance-free three-way catalyst, and a closed crankcase ventilation system.

“Cummins Westport is proud to offer emissions-leading products for our truck and bus customers,” said Rob Neitzke, President of Cummins Westport. “The L9N and B6.7N engines offer customers reliability and performance with near-zero emissions today. Natural gas engines are a mature technology, and are supported by an established fueling and supply infrastructure, enabling fleets to incorporate near-zero emissions technology into their fleets. Cummins Westport’s new 2018 products mean our customers can choose the most affordable path to zero-equivalent emissions with no commercial constraints on supply or technology readiness.”

All CWI engines offer customers the choice of using compressed natural gas (“CNG”), liquefied natural gas (“LNG”), or renewable natural gas (“RNG”) as a fuel. RNG is pipeline-quality natural gas produced from the decomposition of organic waste, which can come from a variety of sources such as dairy farms, landfills, and urban waste treatment plants. Combining Cummins Westport’s ultra low emission engines with RNG fuel provides additional and significant GHG reductions.

For 2018, the L9N and B6.7N will be available as a first-fit option from leading bus and truck manufacturers. Cummins Westport will also introduce the ISX12N natural gas engine as a first-fit option, which like the L9N, will meet the Optional Low NOx emissions level of 0.02 g/bhp-hr. Production of all three engines will begin in the first quarter of 2018.

CWI would like to acknowledge engine development funding support from the Gas Technology Institute, South Coast Air Quality Management District, SoCalGas, and the California Energy Commission.

About Cummins Westport Inc.

Cummins Westport Inc. designs, engineers and markets 6-12 liter spark-ignited natural gas engines for North American commercial transportation applications such as trucks and buses.  Cummins Westport is a joint venture of Cummins Inc. (NYSE:CMI), a corporation of complementary business units that design, manufacture, distribute and service engines and related technologies, including fuel systems, controls, air handling, filtration, emission solutions and electrical power generation systems, and Westport Fuel Systems Inc. (NASDAQ:WPRT) (TSX:WPRT), a global leader in alternative fuel, low-emissions technologies that allow engines to operate on clean-burning fuels such as compressed natural gas (CNG), liquefied natural gas (LNG), hydrogen, and biofuels such as landfill gas. www.cumminswestport.com

Inquiries: 

Westport Fuel Systems Inc.
Caroline Sawamoto
Manager, Investor Relations & Communications
Phone: 604-718-2046
Email: invest@wfsinc.com
Web: www.wfsinc.com

Cummins Inc.
Jon Mills
Director – External Communications
Phone: 317-610-4244
Email: jon.mills@cummins.com
Web: www.cummins.com

Wednesday, December 13th, 2017 Uncategorized Comments Off

$OSTK de Soto and Byrne Unite to Challenge Global Poverty & Inequality

Blockchain used to Create First Global Record of Who Controls Territory and Property Rights

SALT LAKE CITY, Dec. 13, 2017 — World-renowned economist Hernando de Soto and blockchain technology leader Patrick Byrne (founder Overstock.com, Inc. (NASDAQ:OSTK) and blockchain subsidiary Medici Ventures) have formed a joint venture to develop a global property registry system to surface  the property rights of billions of people in the developing world. The new company – De Soto, Inc. – brings together de Soto’s decades worth of reforms (especially regarding property rights) at the Institute for Liberty and Democracy (ILD) and Medici Ventures’ blockchain expertise to build solutions to empower individuals through recognized property ownership.

De Soto, Inc. is developing a blockchain-based system using mobile applications and social media integration that will bring to light the thousands of “disconnected ledgers” (i.e., informal ownership records) that exist at local levels in communities around the world. In doing so, it will create a global repository on which ownership and transfer can be based. The system aims to promote the interests of people who are currently operating extra-legally, as well as multinational corporations who are trying to cooperate with local owners. The company expects to launch its first pilot program in early 2018.

“I envision a world in which people with rights to their property and business assets pull themselves—and their communities —out of poverty,” said de Soto. “About 80 percent of the world’s population is unable to enter into the modern global economy due to lack of visible and standardized property records. Billions of people have resources that cannot easily be transformed into productive capital. Blockchain is a powerful tool to solve these structural issues, which are some of the principal causes of poverty and conflict.”

Considering merely real estate, the poor in developing countries own a staggering $14 trillion in assets that is “dead capital.” In Peru alone, untitled real estate assets amount to $74 billion in value that Peruvians cannot use to establish creditworthiness or leverage as collateral for loans. Lacking formal ownership and the legal protection it affords, citizens of the developing world may turn for protection to terrorist organizations, who gain power by promising enforcement of de facto local property ownership.

Byrne, CEO of Overstock.com and founder of its subsidiary Medici Ventures, has been a longtime advocate for bitcoin and its underlying technology, blockchain. “Working with Hernando de Soto is the honor of my lifetime,” said Byrne. “Hernando’s work has demonstrated that secure ownership of property is a catalyst that sets into motion the engine of progress, creating enormous wealth in the process. From my first public talks on blockchain I emphasized that blockchain’s application to property could lift billions out of poverty. Hernando and I intend to use blockchain technology to empower and enfranchise the five billion people who live outside formal economies within five years.”

“One of our main missions is to democratize capital – to help the poorest members of society participate in global markets,” said Jonathan Johnson, president of Medici Ventures. “Hernando’s work proves that implementing policies to surface and protect property rights undermines terrorist organizations and promotes the prosperity of those who were previously forced to operate outside the formal economic system. Blockchain can solve this problem. It’s great to be partnering with Hernando to bring this vision to reality.”

De Soto is founder and president of the Peru-based Institute for Liberty and Democracy, considered by The Economist to be one of the two most important think tanks in the world. In the last 30 years, de Soto has been designing and implementing legal reforms to empower the poor in Africa, Asia, Latin America, the Middle East, and former Soviet nations through programs that grant access to formal property rights.  De Soto has been written of as “One of the 12 Most Important Economists in the World ”. He  won the prestigious Milton Friedman Prize in 2005, was listed as one of 15 innovators “who will reinvent your future” according to Forbes magazine’s 85th anniversary edition, and has been described by Bill Clinton as “the world’s most important living economist”.

Byrne is the founder/CEO of Overstock.com. Wired Magazine has called Byrne, “The Messiah of Bitcoin”. Byrne has been named the National Entrepreneur of the Year (Ernst & Young, 2011). Overstock has been voted #9 in Employees Choice “Best Places to Work” (Glassdoor, 2011) and named one of the “100 Most Trustworthy Companies in America” (Forbes, 2014).

About Medici Ventures:
Launched in 2014, Medici Ventures is a wholly owned subsidiary of Overstock.com, Inc., created to leverage blockchain technology to solve real-world problems with transparent, efficient and secure solutions. Medici Ventures has a growing portfolio of groundbreaking blockchain-focused investments, including t0.com, Peernova, Bitt, SettleMint, Factom, and IdentityMind, Spera and Symbiont. The company’s majority-owned financial technology company, t0.com, executed the world’s first blockchain-based stock offering in December 2016.

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward-looking statements include all statements other than statements of historical fact. Additional information regarding factors that could materially affect results and the accuracy of the forward-looking statements contained herein may be found in the Company’s Form 10-Q for the quarter ended September 30, 2017, which was filed with the SEC on November 8, 2017, and any subsequent filings with the SEC.

About Overstock.com
Overstock.com, Inc. Common Shares (NASDAQ:OSTK) / Series A Preferred (Medici Ventures’ tZERO platform: OSTKP) / Series B Preferred (OTCQX:OSTBP) is an online retailer based in Salt Lake City, Utah that sells a broad range of products at low prices, including furniture, décor, rugs, bedding, and home improvement. In addition to home goods, Overstock.com offers a variety of products including jewelry, electronics, apparel, and more, as well as a marketplace providing customers access to hundreds of thousands of products from third-party sellers. Additional stores include Pet Adoptions and Worldstock.com dedicated to selling artisan-crafted products from around the world. Forbes ranked Overstock in its list of the Top 100 Most Trustworthy Companies in 2014. Overstock regularly posts information about the company and other related matters under Investor Relations on its website, http://www.overstock.com.

O, Overstock.com, O.com, Club O, Main Street Revolution, and Worldstock are registered trademarks of Overstock.com, Inc. O.biz and Space Shift are also trademarks of Overstock.com, Inc. Other service marks, trademarks and trade names which may be referred to herein are the property of their respective owners.

This press release contains certain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Such forward-looking statements include all statements other than statements of historical fact. Additional information regarding factors that could materially affect results and the accuracy of the forward-looking statements contained herein may be found in the Company’s Form 10-Q for the quarter ended September 30, 2017, which was filed with the SEC on November 8, 2017, and any subsequent filings with the SEC.

SOURCE: Overstock.com, Inc.

Media Contact:
pr@mediciventures.com

Wednesday, December 13th, 2017 Uncategorized Comments Off

$DPW Creates Cryptocurrency Mining Division

Company Signs Agreement to Develop and Manage Digital Mining Farms Worldwide

FREMONT, Calif., Dec. 13, 2017  — Digital Power Corporation (NYSE American:DPW) (“Digital Power” or the “Company“), a company seeking to increase revenues through acquisitions and organic growth, announced today that it has launched a new business division dedicated to the mining of cryptocurrencies. The Company’s initial strategy is to mine the top ten cryptocurrencies including Bitcoin (“BTC”), Ethereum (“ETH”), Bitcoin Cash (“BCH”), Litecoin (“LTC”), Dash (“Dash”) and Monero (“XMR”). To lead the launch and development of the cryptocurrency mining endeavors, the Company has entered a management services agreement with IMG Networks (“IMG”) of San Diego to establish a series of digital mining farms worldwide with a goal of developing a network of over 10,000 digital mining machines.

Digital Power emphasized that its decision to pursue digital mining of cryptocurrencies and establish the new business division was reached through a series of evaluations, research and actions undertaken by the Company and by PoW Digital Mining, the independent consultants contracted by the Company to lead its development of its cryptocurrency endeavors, as previously announced in a press release dated August 10, 2017. Since September 2017, Digital Power and PoW Digital Mining tested an array of digital mining equipment in its efforts to identify initiatives the Company should pursue and lay the basis of their priority. With the Company’s recent decision to create a cryptocurrency mining division, the testing complex has been transitioned to the commercial generation of revenue. Given the recent approval of Bitcoin to be publicly-traded over two U.S. national exchanges (Chicago Board Options Exchange (“CBOE”) Futures Exchange (“CFE”) and Chicago Mercantile Exchange) and other advances with respect to government regulation and more general acceptance of cryptocurrency by commercial businesses, the Company believes these circumstances bolster the strength of its internal forecasts and enhance the viability of its new business development strategy. The Company believes that it has a competitive advantage based on the following factors:

  1. Over forty-eight (48) years of developing and manufacturing advanced power solutions to some of the most iconic businesses on the Fortune 500.
  2. The ability to leverage its existing infrastructure, capacity and excess space at the various manufacturing facilities of Digital Power and its subsidiaries. These facilities comply with applicable governmental or military requirements with agency-issued certificates corroborating these facts. Moreover, each facility has readily available military-grade power solutions to operate digital mining operations. The Company believes its ability to exploit the inherent attributes of its facilities in Northern and Southern California, Connecticut and Great Britain will reduce initial costs and help shorten the time requirement to establish digital mining operations at these locations.
  3. The thirteen (13) years of technical and practical experience of IMG in Information Technology such as server administration, network engineering or, in this case, digital mining farms.

IMG Network’s expertise lies in information technology, software development, network engineering, and web development and programming. IMG serves both commercial and defense contracts. IMG is involved with several governmental contract vehicles including the U.S. Navy’s Seaport-E and the GSA Stars II Governmentwide Acquisition Contract. IMG Networks, a division of Imagine Media Group, LLC, is a California limited liability company formed in 2004. IMG holds several small business certifications at all government levels including a Small Business Administration (SBA) 8(a), a Small Business designation with the California Department of General Services, and ELBE with the City of San Diego. As a service provider, the core competency of IMG is contract management; in addition, in its capacity as a solutions provider, IMG combines a wide array of technical expertise with a customer-centric philosophy focused on meeting mission needs.

The Company also disclosed today that it has been made aware of numerous unfounded and unsubstantiated inquiries and rumors but cannot address each and every one of them. However, Digital Power reminds all shareholders, investors and the public that its many years of manufacturing quality products, cultivation and retention of long-term clients and leading innovation should speak for itself as the Company continues to pursue new endeavors while expanding current revenue streams for the benefit of all interested parties. To maintain the maximum transparency with shareholders, investors and the public, the Company intends to use its best efforts to provide complete and contemporaneous disclosure of its operations.

The Company also reminds shareholders, investors and the public that it will be hosting an online webinar for its shareholders, investors and the public on Wednesday, December 20, 2017, upon the close of the financial markets that day. All individuals interested in participating in the webinar can email the Company to participate at info@digitalpowercorp.com.

ABOUT DIGITAL POWER

Headquartered in Fremont, CA, Digital Power Corporation, through its subsidiaries, designs, manufactures and sells high-grade customized and off-the-shelf power system solutions. Our products are used in the most demanding communications, industrial, medical and military applications where customers demand high density, high efficiency and rugged power solutions. The Company’s wholly owned subsidiary, Coolisys Technologies, Inc., is dedicated to providing world-class technology-based solutions where innovation is the main driver for mission-critical applications and lifesaving services. Coolisys’ growth strategy targets core markets that are characterized by “high barriers to entry” and include specialized products and services not likely to be commoditized. Coolisys Technologies, Inc., a developer and manufacturer that services the defense, aerospace, medical and industrial sectors, has three subsidiaries including Digital Power Limited dba Gresham Power Ltd., www.GreshamPower.com, a manufacturer based in Salisbury, UK.; Microphase Corporation, www.MicroPhase.com with its headquarters in Shelton, CT 1- 203-866-8000; and Power-Plus Technical Distributors, www.Power-Plus.com, a wholesale distributor based in Sonora, CA 1-800-963-0066.

Digital Power Lending, LLC, is a wholly owned subsidiary of the Company, is based in Fremont, CA, and is a California private lending company dedicated to strategically providing capital to small and middle size businesses for an equity interest in addition to loan fees and interest, www.DigitalPowerLending.com. Excelo, LLC, a wholly-owned subsidiary of the Company, is a national search firm specializing in fulfilling strategic executive, professional and hi-tech placements for businesses delivering world-class services, www.Excelo.com. Digital Power Corporation’s headquarters is located at 48430 Lakeview Blvd., Fremont, California, 94538; 1-877-634-0982; www.DigiPwr.com.

For Investor inquiries: IR@digipwr.com, www.DigitalPowerCorp.com or 1-888-753-2235.

Forward-Looking Statements

The foregoing release contains “forward looking statements” regarding future events or results within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, including statements concerning the Company’s current expectations regarding revenues for the remaining 2017 and thereafter from contracts and operations on a consolidated basis, the Company’s ability to continue to finance its current operations, the ability of the Company to finance or complete the manufacturing of its new product line for the digital mining community, the ability of the Company to sell digital mining power systems or the ability to raise sufficient capital to establish digital mining farms or its ability to operate successfully those farms and be profitable. The Company cautions readers that such “forward looking statements” are, in fact, predictions that are subject to risks and uncertainties and that actual events or results may differ materially from those anticipated events or results expressed or implied by such forward- looking statements. The Company disclaims any current intention to update its “forward looking statements,” and the estimates and assumptions within them, at any time or for any reason, unless required by applicable law. More information, including potential risk factors, that could affect the Company’s business and financial results are included in the Company’s filings with the U.S. Securities and Exchange Commission, including, but not limited to, the Company’s Forms 10-K, 10-Q and 8-K. All filings are available at www.sec.gov and on the Company’s website at www.DigitalPowerCorp.com.

Wednesday, December 13th, 2017 Uncategorized Comments Off

$BSQR Partners with $AMZN $MSFT Industrial IoT Data Visualizations

Amazon QuickSight and Microsoft’s Power BI help DataV customers rapidly build and share custom cross-system reports that include complex and critical IIoT data

BELLEVUE, Wash., Dec. 12, 2017  – Bsquare (NASDAQ: BSQR), a provider of Industrial Internet of Things (IIoT) solutions, today announced new DataV software integrations with Amazon QuickSight and Microsoft’s Power BI that allow industrial organizations to quickly create and share powerful new cross-system interactive data visualizations and reports. Customers can now leverage these popular reporting platforms to take connected device information from within DataV and combine it with other enterprise system data to create new data views that can be critical for business success.

“Data generated from connected equipment is allowing industrial companies to make quicker and more accurate decisions about their business,” said Dave McCarthy, Senior Director, Products at Bsquare. “The ability to quickly create new visualizations of that information by combining it with other data – and easily sharing the results with others in the organization – is critical to achieving that goal. DataV currently offers native reporting based on the functionality within our apps. By providing an open standard connection to tools from third party vendors like Amazon and Microsoft, we’re helping customers extend the value they can get out of their IIoT data sets.”

With connected endpoints in businesses poised to grow from 3 billion in 2017 to 7.5 billion by 2020, being able to capture device data and turn it into actionable intelligence is fundamentally changing how industrial organizations operate. From predicting equipment failures to better utilization of assets, DataV already helps organizations drive powerful business outcomes from connected device data. These new integrations help extend the functionality of DataV so customers can build even more powerful cross-system visualizations and reports. Teams can create custom visualizations or select from a list of pre-built reports that map to the apps available in DataV.

DataV enables industrial organizations, such as those in manufacturing, transportation, and oil and gas industries to use data generated by connected devices to make smarter operational decisions. DataV IoT applications and platform help businesses translate insights generated by industrial assets into critical operational improvements, such as better managing devices, increasing production volume, or reducing operating costs. Visualization tools are a critical component to realizing these and other benefits from IIoT.

Amazon QuickSight is a fast, cloud-powered business analytics service that makes it easy to build visualizations, perform ad-hoc analysis, and quickly get business insights from data. Power BI from Microsoft is a suite of business analytics tools that enable organizations to connect to hundreds of data sources, simplify data prep and drive analysis. Rich, custom visualizations can be viewed from browsers or mobile devices. DataV also integrates with the Tableau visual analytics platform.

To learn more about how DataV is driving powerful business outcomes from IIoT, visit: https://www.bsquare.com/datav/

About Bsquare
For more than two decades, Bsquare has helped its customers extract business value from a broad array of physical assets by making them intelligent, connecting them, and using the data they generate to optimize business processes. Bsquare DataV software solutions can be deployed by a wide variety of enterprises to create business-focused Internet of Things (IoT) systems that more effectively monitor device data, automate processes, predict events and produce better business outcomes. Bsquare goes a step further by coupling its purpose-built DataV software with comprehensive analytic and engineering services that can help organizations of all types make IoT a business reality. For more information, visit www.bsquare.com.

BSQUARE, the BSQUARE Logo and DataV are trademarks of BSQUARE Corporation in the U.S. and other countries. Other names and brands herein may be trademarks of others.

Tuesday, December 12th, 2017 Uncategorized Comments Off

$GLYC Improvements in Median Overall Survival Phase 1/2 Trial for GMI-1271 in AML

ROCKVILLE, Md.

  • Clinical outcomes, including durability of remission and median overall survival, in high-risk patients plus safety and tolerability data presented in oral presentation at American Society of Hematology Annual Meeting and Expo
  • Second oral presentation highlights underlying, differentiated mechanism of action for company’s lead clinical candidate

GlycoMimetics, Inc. (NASDAQ: GLYC) today announced updated data from the Phase 1/2 trial evaluating the safety, tolerability and efficacy of GMI-1271 in patients with relapsed/refractory (R/R) acute myeloid leukemia (AML) and in older adults with newly diagnosed AML, including the following conclusions:

For patients with R/R AML treated at the Phase 2 dose (n = 54) and for whom median follow up was 6.6 months:

  • Clinical remission (CR+CRi) was 43%.
  • Median overall survival was 9.4 months (95% CI: 5.7 – 15.1 months; calculated by Kaplan Meier method). This compares favorably to a median overall survival of up to 5.4 months reported for historical, matched controls treated with mitoxantrone, etoposide and cytarabine (MEC) alone. 1,2
  • Median duration of remission was 11.1 months (95% CI: 5.8-NA; calculated by Kaplan Meier method).

For older patients with newly diagnosed disease (n=25) and for whom median follow up was 10.5 months:

  • Clinical remission rate was 68%.
  • Median overall survival was 15.8 months (95% CI: 10.3 – NA; calculated by Kaplan Meier method). This compares favorably to a historical median overall survival of approximately 12 months in matched controls treated with 7+3 chemotherapy alone. 3,4
  • Median duration of remission was 14.8 months (95% CI: 8.3 – NA; calculated by Kaplan Meier method).
  • Median event free survival was 11.3 months.

The data were presented yesterday during an oral scientific session at the 59th American Society of Hematology (ASH) Annual Meeting and Expo in Atlanta.

Across both populations, GMI-1271 was well tolerated with no obvious incremental toxicity observed and lower than expected rates of severe, debilitating, grade 3-4 mucositis reported (e.g., 3% incidence reported vs. historical 20-25% incidence with MEC alone).

“These new data from our Phase 1/2 clinical trial demonstrate that encouraging clinical outcomes are possible for both duration of remission and survival endpoints when GMI-1271 is added to chemotherapy in two distinct AML patient populations,” noted Helen Thackray, M.D., FAAP, GlycoMimetics Senior Vice-President, Clinical Development and Chief Medical Officer. “Beyond the high response rates previously reported with GMI-1271, we can now point to additional long-term endpoints that further support our plan to move the drug candidate into a Phase 3 clinical trial scheduled to begin in mid-2018. Importantly, with respect to safety, the low mucositis rate in relapsed and refractory patients receiving MEC induction chemotherapy — where you would expect around 25% severe mucositis — is quite striking. This was predicted and explained by preclinical models in which GMI-1271 blocked inflammatory macrophages trafficking to the gut and thus prevented mucosal injury.”

“These results continue to show that AML patients treated with GMI-1271 consistently perform better than expected,” said Daniel J. DeAngelo, M.D., Ph.D., the trial’s lead investigator and Director of Clinical and Translational Research, Adult Leukemia Program, at the Dana-Farber Cancer Institute and Brigham and Women’s Hospital, who presented the data at the ASH Annual Meeting. “Our Phase 2 population consists of very high-risk patients based on age, disease status, and cytogenetic risk factors. The updated data continue to support the concept that disrupting the relationship between leukemic cells and the protective bone marrow microenvironment, when combined with chemotherapy, could improve the outlook and prognosis for these patients.”

The second oral presentation at the ASH meeting highlighted a preclinical study in murine models of AML in which E-selectin was shown to be upregulated, and AML cells binding to E-selectin increased chemo-resistance by activating specific tumor cell survival signaling pathways. This effect within the bone marrow microenvironment is unique to E-selectin as compared to other vascular adhesion molecules and can be blocked by GMI-1271. This translational research provides important evidence that elucidates how treatment with GMI-1271 appears to be improving sensitivity to chemotherapy.

“Given response rates we’ve observed to date that suggest clinical benefit in combination with chemotherapy in two AML populations, this preclinical work provides important further support for the mechanism of action of GMI-1271,” noted Dr. Thackray. “Together, the clinical and preclinical data we have shared at the ASH Annual Meeting demonstrate that GMI-1271 could represent a novel and truly differentiated approach to treatment of AML,” Dr. Thackray concluded.

Meeting abstracts are available on ASH’s website.

GlycoMimetics to Hold Post-ASH Meeting Briefing in Boston on December 19

GlycoMimetics will hold a briefing for investors/analysts, which will also be available via webcast, to review the GMI-1271 program with a focus on the AML clinical data presented at the ASH Annual Meeting, at the Langham Hotel in Boston, December 19, at 7:30 a.m. EST. Dr. DeAngelo will present the clinical data from the ASH oral presentation and respond to questions from on-site participants.

About GlycoMimetics, Inc.

GlycoMimetics is a clinical-stage biotechnology company focused on the discovery and development of novel glycomimetic drugs to address unmet medical needs resulting from diseases in which carbohydrate biology plays a key role. GlycoMimetics’ first drug candidate, rivipansel, a pan-selectin antagonist, is being developed for the treatment of vaso-occlusive crisis in sickle cell disease and is being evaluated in a Phase 3 clinical trial being conducted by its strategic collaborator, Pfizer. GlycoMimetics’ wholly-owned drug candidate, GMI-1271, a specific E-selectin antagonist, has been evaluated in a Phase 1/2 clinical trial as a potential treatment for AML and is currently being evaluated in an ongoing Phase 1 clinical trial for the treatment of multiple myeloma. The U.S. Food and Drug Administration has granted GMI-1271 Breakthrough Therapy designation for the treatment of adult AML patients with relapsed/refractory disease. GlycoMimetics has also conducted a Phase 1 clinical trial with a third drug candidate, GMI-1359, a combined CXCR4 and E-selectin antagonist. GlycoMimetics is located in Rockville, MD in the BioHealth Capital Region. Learn more at www.glycomimetics.com.

Cautionary Note Regarding Forward-Looking Statements

This press release contains forward-looking statements regarding the clinical development of GMI-1271, including the expected timing of clinical trials and the presentation of clinical data. Actual results may differ materially from those in these forward-looking statements. For a further description of the risks associated with these statements, as well as other risks facing GlycoMimetics, please see the risk factors described in the company’s annual report on Form 10-K that was filed with the U.S. Securities and Exchange Commission (SEC) on March 1, 2017, and other filings GlycoMimetics makes with the SEC from time to time. Forward-looking statements speak only as of the date of this release, and GlycoMimetics undertakes no obligation to update or revise these statements, except as may be required by law.

References

1. Feldman EJ, Brandwein J, Stone R, et al. Phase III randomized multicenter study of a humanized anti-CD33 monoclonal antibody, lintuzumab, in combination with chemotherapy, versus chemotherapy alone in patients with refractory or first-relapsed acute myeloid leukemia. Journal of clinical oncology. 2005;23(18):4110-4116. 47.

2. Greenberg PL, Lee SJ, Advani R, et al. Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995). Journal of clinical oncology. 2004;22(6):1078-1086

3. Foran JM, Sun Z, Claxton DF, et al. North American Leukemia, Intergroup phase III randomized trial of single agent clofarabine as induction and post-remission therapy, and decitabine as maintenance therapy in newly-diagnosed acute myeloid leukemia in older adults (age≥ 60 years): A trial of the ECOG-ACRIN Cancer Research Group (E2906). Blood. 2015;126(23):217-217. 45.

4. Lancet JE, Cortes JE, Hogge DE, et al. Phase 2 trial of CPX-351, a fixed 5:1 molar ratio of cytarabine/daunorubicin, vs cytarabine/daunorubicin in older adults with untreated AML. Blood. 2014;123(21):3239-3246.

 

GlycoMimetics, Inc.
Investor Contact:
Shari Annes, 650-888-0902
sannes@annesassociates.com
or
Media Contact:
Jamie Lacey-Moreira, 410-299-3310
jamielacey@presscommpr.com

Tuesday, December 12th, 2017 Uncategorized Comments Off